KLHL7

Across TCGA pan-cancer cohorts, KLHL7 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated KLHL7 data layer compared with 24 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher KLHL7 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLHL7 expression acts as an unfavorable survival marker.

KIRP, LUAD, and KIRC are the cancer types where KLHL7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.088	0.920	<.001	48	view →
LUAD	OS	Median	III,IV	0.083	0.680	<.001	28	view →
KIRC	DFS	Median	All	0.211	0.628	.018	26	view →
LUSC	OS	Median	All	0.248	0.680	<.001	24	view →
ACC	OS	Median	All	0.273	0.802	.017	15	view →
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →
LIHC	OS	Median	All	0.098	0.774	.001	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
MESO	OS	Median	All	0.169	0.556	.043	3	view →
SKCM	OS	Median	III,IV	0.176	0.698	.007	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

KLHL7–KIRP (DFS)

Open the KIRP breakdown →