KLHL7

Across TCGA pan-cancer cohorts, KLHL7 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of KLHL7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KLHL7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KLHL7 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LUAD, and LIHC are the cancer types where KLHL7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHL7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.837	<.001	12	view →
LUAD	All	IV	+1.240	<.001	9	view →
LIHC	Male	All	+0.877	<.001	9	view →
KIRP	All	II,III,IV	+0.530	.002	9	view →
BLCA	All	All	+0.523	.002	8	view →
CHOL	Male	All	+1.701	<.001	5	view →
LUSC	Male	All	+0.560	<.001	5	view →
THCA	All	All	−0.197	.019	3	view →
ESCA	All	All	+0.544	.008	2	view →
KICH	All	All	−0.465	.006	2	view →
STAD	All	II,III,IV	+0.456	.032	2	view →
BRCA	Female	All	−0.163	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

KLHL7–HNSC

Open the HNSC breakdown →