KLHL7

Across TCGA patient cohorts, KLHL7 protein abundance is significantly associated with the RNA expression of many other genes, with 17,735 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KLHL7-associated genes across cancer lineages are RAD51AP1, CCDC77, and GARS1. Each is linked with KLHL7 in more than 4 cancer types. Because this analysis shows association rather than direction, both KLHL7-to-partner and partner-to-KLHL7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL7 versus RAD51AP1 in BRCA, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL7→partner) and Y-score (partner→KLHL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RAD51AP1 →	+1.158	+0.306	<.001	<.001	3	5
LSCC	CCDC77 →	+0.756	+0.340	<.001	<.001	3	5
BRCA	GARS1 →	+0.613	+0.324	<.001	<.001	3	5
HNSC	PIK3CG →	-0.791	-0.491	.003	.003	3	4
OV	SLC2A9 →	-1.153	-0.510	<.001	.004	3	4
OV	PTPN7 →	-0.909	-0.450	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,735 associations by consensus.

KLHL7 vs RAD51AP1 — BRCA

Explore this scatter interactively →