KLHL7

Across TCGA patient cohorts, KLHL7 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL7-associated genes across cancer lineages are eEF2, p38-MAPK_pT180_Y182, and p62 Lck ligand. Each is linked with KLHL7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL7-to-partner and partner-to-KLHL7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by KLHL7-low versus KLHL7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL7→partner) and Y-score (partner→KLHL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.269	+1.765	.044	.014	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.384	-2.000	.023	.030	3	2
UCEC	p62 Lck ligand →	+0.380	+2.916	.001	<.001	3	2
UCEC	PCNA →	+0.263	+2.662	.001	<.001	3	2
UCEC	14-3-3_beta →	-0.099	-3.295	.008	.009	3	1
UCEC	EGFR_pY1068 →	-0.309	-2.906	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eEF2 by KLHL7 expression — UCEC

Explore this box plot interactively →