KLHL7

Across TCGA cell cohorts, KLHL7 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL7-associated genes across cancer lineages are MYOD1, KRTAP6-3, and CNTN3. Each is linked with KLHL7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL7-to-partner and partner-to-KLHL7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYOD1 grouped by KLHL7-low versus KLHL7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL7→partner) and Y-score (partner→KLHL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYOD1 →	+0.022	+4.922	<.001	.009	3	1
BLOOD_Leukemia	KRTAP6-3 →	+0.250	+6.569	<.001	<.001	3	1
LARGE_INTESTINE	CNTN3 →	+0.344	+3.029	<.001	.005	3	1
LARGE_INTESTINE	SIRPD →	+0.015	+2.977	<.001	.006	3	1
LARGE_INTESTINE	FAM153CP →	+0.257	+3.215	.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MYOD1 by KLHL7 expression — BLOOD_Leukemia

Explore this box plot interactively →