KLHL7-DT

Across TCGA pan-cancer cohorts, KLHL7-DT RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated KLHL7-DT data layer.

The strongest signal is observed in thymoma (THYM), where higher KLHL7-DT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KLHL7-DT expression acts as an unfavorable survival marker, although some lineages such as THYM and UCS show a favorable association.

THYM, UCS, and KIRP are the cancer types where KLHL7-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Median	II,III,IV	0.898	0.562	<.001	54	view →
UCS	DFS	Median	III,IV	0.564	0.281	.019	42	view →
KIRP	OS	Quartile	All	0.604	0.860	.003	39	view →
LUAD	OS	Quartile	III,IV	0.778	0.462	<.001	37	view →
DLBC	DFS	Median	All	0.908	0.287	<.001	30	view →
MESO	OS	Median	IV	0.349	0.781	.013	18	view →
LIHC	OS	Tertile	All	0.709	0.841	.001	18	view →
COAD	OS	Median	II,III,IV	0.487	0.691	.006	14	view →
UVM	DFS	Median	III,IV	0.292	0.745	.014	9	view →
CHOL	DFS	Median	All	0.249	0.633	.040	9	view →
LAML	DFS	Quartile	All	0.252	0.585	.039	6	view →
OV	DFS	Median	III,IV	0.565	0.498	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

KLHL7-DT–THYM (DFS)

Open the THYM breakdown →