KLHL7-DT

Across TCGA pan-cancer cohorts, KLHL7-DT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KLHL7-DT’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where KLHL7-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KLHL7-DT is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

LUAD, LIHC, and HNSC are the cancer types where KLHL7-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHL7-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+0.769	<.001	9	view →
LIHC	Male	All	+0.401	<.001	8	view →
HNSC	All	All	+0.351	<.001	8	view →
KIRC	All	All	−0.252	.004	6	view →
LUSC	All	All	+0.516	<.001	5	view →
COAD	All	All	+0.343	.001	5	view →
KICH	All	All	−0.686	<.001	4	view →
CHOL	Male	All	+0.311	.005	4	view →
STAD	All	All	+0.305	.032	4	view →
THCA	All	All	−0.318	.002	2	view →
PRAD	All	All	+0.244	.031	2	view →
BLCA	Female	III,IV	+0.502	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KLHL7-DT–LUAD

Open the LUAD breakdown →