KLHL6-AS1

Across TCGA pan-cancer cohorts, KLHL6-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated KLHL6-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher KLHL6-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KLHL6-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CESC show a favorable association.

KIRP, UVM, and LUAD are the cancer types where KLHL6-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.626	0.861	<.001	71	view →
UVM	DFS	Tertile	All	0.360	0.777	.005	36	view →
LUAD	DFS	Tertile	II,III,IV	0.693	0.345	.001	35	view →
CESC	DFS	Tertile	All	0.861	0.700	.006	24	view →
SKCM	DFS	Tertile	II,III,IV	0.297	0.192	.009	20	view →
LUSC	OS	Median	II,III,IV	0.291	0.527	.003	19	view →
PAAD	OS	Quartile	All	0.195	0.511	.002	18	view →
BLCA	DFS	Median	II,III,IV	0.418	0.282	.007	17	view →
KIRC	DFS	Quartile	III,IV	0.781	0.579	.012	16	view →
UCEC	DFS	Tertile	III,IV	0.700	0.837	.021	12	view →
STAD	DFS	Median	IV	0.138	0.500	.028	9	view →
COAD	DFS	Tertile	IV	0.294	0.528	.030	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

KLHL6-AS1–KIRP (OS)

Open the KIRP breakdown →