KLHL6-AS1

Across TCGA pan-cancer cohorts, KLHL6-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KLHL6-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KLHL6-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KLHL6-AS1 is over-expressed in tumor, although a few such as KICH and LIHC show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where KLHL6-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHL6-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	+1.124	<.001	12	view →
HNSC	All	All	+0.131	<.001	9	view →
KICH	All	II,III,IV	−0.980	<.001	7	view →
LIHC	Male	II,III,IV	−1.255	<.001	5	view →
KIRP	All	All	−0.451	.006	4	view →
CHOL	Male	All	−1.850	<.001	2	view →
BLCA	All	All	+0.376	.042	2	view →
STAD	All	All	+0.317	.047	1	view →
LUAD	Male	III,IV	−0.196	.023	1	view →
LUSC	Female	II,III,IV	−0.191	.041	1	view →
READ	All	All	+0.156	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

KLHL6-AS1–KIRC

Open the KIRC breakdown →