KLHL5

Across TCGA pan-cancer cohorts, KLHL5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KLHL5 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher KLHL5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KLHL5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where KLHL5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.559	0.916	.023	6	view →
CCRCC	OS	Median	II,III,IV	0.893	0.321	.020	4	view →
PDAC	OS	Quartile	All	0.520	0.884	.038	4	view →
LUAD	OS	Tertile	II,III,IV	0.291	0.764	.033	4	view →
GBM	OS	Quartile	All	0.683	0.849	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KLHL5–LSCC (OS)

Open the LSCC breakdown →