KLHL5

Across TCGA patient cohorts, KLHL5 protein abundance is significantly associated with the RNA expression of many other genes, with 3,224 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KLHL5-associated genes across cancer lineages are MMP28, SPP1, and FRMD6. Each is linked with KLHL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL5-to-partner and partner-to-KLHL5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL5 versus MMP28 in UCEC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL5→partner) and Y-score (partner→KLHL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MMP28 →	+0.774	+0.399	.008	.008	3	3
PDAC	SPP1 →	+1.306	+0.867	.005	.002	3	2
BRCA	FRMD6 →	+0.794	+0.257	<.001	.004	3	2
BRCA	PIP4P2 →	+0.700	+0.528	.002	<.001	3	2
BRCA	RBPJ →	+0.480	+0.364	<.001	.004	3	2
BRCA	CAVIN1 →	+0.911	+0.534	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,224 associations by consensus.

KLHL5 vs MMP28 — UCEC

Explore this scatter interactively →