KLHL5

Across TCGA patient cohorts, KLHL5 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL5-associated genes across cancer lineages are ASNS, 4E-BP1, and C-Raf. Each is linked with KLHL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL5-to-partner and partner-to-KLHL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by KLHL5-low versus KLHL5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL5→partner) and Y-score (partner→KLHL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.607	+3.708	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.374	+3.730	<.001	<.001	3	2
UCEC	C-Raf →	+0.227	+2.169	<.001	.003	3	2
UCEC	p62 Lck ligand →	+0.288	+2.009	.018	.017	3	2
COAD	p53 →	-0.267	-3.000	.049	.035	3	1
COAD	Src →	-0.216	-3.157	.008	.018	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ASNS by KLHL5 expression — COAD

Explore this box plot interactively →