KLHL5

Across TCGA cell cohorts, KLHL5 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,876 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL5-associated GO terms across cancer lineages are Cellular response to environmental stimulus, Regulation of cell-substrate adhesion, and Regulation of cell-matrix adhesion. Each is linked with KLHL5 in more than 12 cancer types. Because this analysis shows association rather than direction, both KLHL5-to-partner and partner-to-KLHL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to environmental stimulus grouped by KLHL5-low versus KLHL5-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL5→partner) and Y-score (partner→KLHL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Cellular response to environmental stimulus →	+0.044	+1.922	<.001	<.001	3	13
BONE	Regulation of cell-substrate adhesion →	+0.166	+2.030	<.001	<.001	3	13
BONE	Regulation of cell-matrix adhesion →	+0.200	+1.916	<.001	<.001	3	13
LARGE_INTESTINE	Cellular response to abiotic stimulus →	+0.044	+1.922	<.001	<.001	3	13
BREAST	Negative regulation of wound healing, spreading of epidermal cells →	+0.155	+1.819	<.001	<.001	3	12
BONE	Endothelial cell differentiation →	+0.158	+2.049	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,876 associations by consensus.

Cellular response to environmental stimulus by KLHL5 expression — LARGE_INTESTINE

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