KLHL40

Across TCGA patient cohorts, KLHL40 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL40-associated genes across cancer lineages are 4E-BP1, Akt_pT308, and EGFR_pY1068. Each is linked with KLHL40 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL40-to-partner and partner-to-KLHL40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by KLHL40-low versus KLHL40-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL40→partner) and Y-score (partner→KLHL40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.299	+3.169	.042	.019	3	3
UCEC	Akt_pT308 →	+0.471	+2.321	.034	.033	3	3
UCEC	EGFR_pY1068 →	-0.226	-2.584	.010	.010	3	2
COAD	INPP4B →	-0.549	-3.169	<.001	.017	3	2
UCEC	PCNA →	+0.181	+1.662	.017	.011	3	2
UCEC	PDCD4 →	-0.346	-1.362	.037	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

4E-BP1 by KLHL40 expression — STAD

Explore this box plot interactively →