KLHL40

Across TCGA pan-cancer cohorts, KLHL40 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated KLHL40 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher KLHL40 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KLHL40 expression acts as an unfavorable survival marker, although some lineages such as LUAD and ESCA show a favorable association.

KICH, HNSC, and MESO are the cancer types where KLHL40 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Quartile	II,III,IV	0.589	0.923	<.001	42	view →
HNSC	OS	Median	III,IV	0.674	0.813	.002	36	view →
MESO	OS	Tertile	IV	0.115	0.671	<.001	30	view →
SCLC	OS	Tertile	IV	0.164	0.599	.001	30	view →
LIHC	OS	Tertile	II,III,IV	0.445	0.645	.008	27	view →
LUAD	DFS	Quartile	All	0.871	0.761	.009	26	view →
TGCT	DFS	Tertile	All	0.470	0.781	<.001	24	view →
ESCA	OS	Tertile	III,IV	0.616	0.322	.014	18	view →
DLBC	OS	Tertile	III,IV	0.272	1.000	.017	16	view →
UVM	DFS	Tertile	III,IV	1.000	0.538	.011	13	view →
CESC	OS	Tertile	III,IV	0.935	0.676	.035	10	view →
ACC	OS	Tertile	IV	0.799	0.381	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

KLHL40–KICH (OS)

Open the KICH breakdown →