KLHL40

Across TCGA cell cohorts, KLHL40 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,389 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible KLHL40-associated GO terms across cancer lineages are Regulation of mRNA catabolic process, Positive regulation of telomere capping, and Regulatory ncRNA-mediated gene silencing. Each is linked with KLHL40 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLHL40-to-partner and partner-to-KLHL40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA catabolic process grouped by KLHL40-low versus KLHL40-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL40→partner) and Y-score (partner→KLHL40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of mRNA catabolic process →	+0.062	+1.182	<.001	.003	3	4
SKIN	Positive regulation of telomere capping →	+0.092	+0.003	.003	.003	3	4
SOFT_TISSUE	Regulatory ncRNA-mediated gene silencing →	+0.081	+1.021	<.001	.007	3	4
PANCREAS	Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway →	+0.103	+0.004	.004	.003	2	4
SOFT_TISSUE	Regulation of mRNA splicing, via spliceosome →	+0.071	+0.934	<.001	.003	3	3
PANCREAS	Response to oxygen levels →	+0.030	+0.004	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,389 associations by consensus.

Regulation of mRNA catabolic process by KLHL40 expression — SOFT_TISSUE

Explore this box plot interactively →