KLHL40

Across TCGA cell cohorts, KLHL40 mutation is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLHL40-associated genes across cancer lineages are C5orf52, OR1L3, and SEL1L2. Each is linked with KLHL40 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL40-to-partner and partner-to-KLHL40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf52 grouped by KLHL40-low versus KLHL40-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL40→partner) and Y-score (partner→KLHL40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C5orf52 →	+0.030	+4.415	<.001	.007	3	2
OVARY	OR1L3 →	+0.039	+4.029	<.001	.009	3	2
URINARY_TRACT	SEL1L2 →	+0.022	+4.087	<.001	.009	3	1
URINARY_TRACT	OTOR →	+0.022	+4.087	<.001	.009	3	1
URINARY_TRACT	PRRG3 →	+0.005	+4.087	<.001	.009	3	1
URINARY_TRACT	PABPC1L2B →	+0.010	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

C5orf52 by KLHL40 expression — SKIN

Explore this box plot interactively →