KLHL4

Across TCGA patient cohorts, KLHL4 protein abundance is significantly associated with the RNA expression of many other genes, with 1,955 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KLHL4-associated genes across cancer lineages are NECTIN4, F11R, and GOLGA2P7. Each is linked with KLHL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL4-to-partner and partner-to-KLHL4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL4 versus NECTIN4 in UCEC, with a Pearson correlation of -0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL4→partner) and Y-score (partner→KLHL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NECTIN4 →	-0.861	-0.365	.007	.005	3	2
UCEC	F11R →	-0.714	-0.609	.003	<.001	3	2
UCEC	GOLGA2P7 →	-0.431	-0.474	.003	.007	3	2
UCEC	IGSF9 →	-1.532	-0.562	.002	.004	3	2
LUAD	GJA3 →	-0.202	-0.303	.002	.008	3	1
LUAD	LDHA →	+0.464	+0.371	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,955 associations by consensus.

KLHL4 vs NECTIN4 — UCEC

Explore this scatter interactively →