KLHL38

Across TCGA patient cohorts, KLHL38 mutation is significantly associated with the RNA expression of many other genes, with 1,521 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL38-associated genes across cancer lineages are UQCR10P1, RNA5SP457, and C19orf47. Each is linked with KLHL38 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL38-to-partner and partner-to-KLHL38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UQCR10P1 grouped by KLHL38-low versus KLHL38-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL38→partner) and Y-score (partner→KLHL38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	UQCR10P1 →	+0.301	+4.259	.002	.001	3	3
LIHC	RNA5SP457 →	+0.246	+4.564	<.001	.006	3	2
UCEC	C19orf47 →	+0.366	+2.127	.001	.002	3	2
UCEC	CFL2 →	+0.573	+3.753	<.001	<.001	3	2
UCEC	CHAF1A →	+0.487	+3.502	.002	.002	3	2
UCEC	UBXN6 →	+0.335	+2.928	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,521 associations by consensus.

UQCR10P1 by KLHL38 expression — LUSC

Explore this box plot interactively →