KLHL35

Across TCGA patient cohorts, KLHL35 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL35-associated genes across cancer lineages are EGFR, Rab11, and S6_pS240_S244. Each is linked with KLHL35 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL35-to-partner and partner-to-KLHL35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by KLHL35-low versus KLHL35-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL35→partner) and Y-score (partner→KLHL35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.277	-3.000	.002	.037	3	1
UCEC	Rab11 →	-0.175	-3.000	.036	.037	3	1
UCEC	S6_pS240_S244 →	+0.478	+3.000	.042	.036	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.733	+2.817	.012	.036	2	1
UCEC	Caspase-8 →	-0.324	-3.000	.026	.036	2	1
UCEC	Di-Ras3 →	-0.180	-3.000	.036	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

EGFR by KLHL35 expression — UCEC

Explore this box plot interactively →