KLHL35

Across TCGA cell cohorts, KLHL35 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLHL35-associated genes across cancer lineages are FAM25G, CLPS, and SRY. Each is linked with KLHL35 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL35-to-partner and partner-to-KLHL35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM25G grouped by KLHL35-low versus KLHL35-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL35→partner) and Y-score (partner→KLHL35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAM25G →	+0.493	+4.269	<.001	.005	3	1
LUNG_NSCLC_LUAD	CLPS →	+0.132	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	SRY →	+0.062	+4.544	<.001	.003	3	1
LARGE_INTESTINE	ADH1A →	+0.132	+3.920	.001	.005	3	1
BLOOD_Leukemia	TCF21 →	+0.011	+4.705	<.001	.003	3	1
BLOOD_Leukemia	TACR3 →	+0.038	+5.060	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

FAM25G by KLHL35 expression — LUNG_SCLC

Explore this box plot interactively →