Across TCGA patient cohorts, KLHL34 protein abundance is significantly associated with the RNA expression of many other genes, with 606 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible KLHL34-associated genes across cancer lineages are ILVBL, WDR35, and SFRP1. Each is linked with KLHL34 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL34-to-partner and partner-to-KLHL34 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL34→partner) and Y-score (partner→KLHL34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ILVBL →	+0.522	+0.481	.004	.006	3	2
BRCA	WDR35 →	-0.491	-0.446	<.001	<.001	3	2
LUAD	SFRP1 →	-0.613	-0.334	.001	<.001	3	1
LUAD	TRMT1 →	+0.307	+0.266	.002	.008	3	1
LUAD	STX10 →	+0.419	+0.361	<.001	.001	3	1
LUAD	C19orf53 →	+0.283	+0.382	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 606 associations by consensus.

Exploration

KLHL34 survival (RNA) · tumor vs normal (RNA) · all KLHL34 data types