Across TCGA patient cohorts, KLHL33 mutation is significantly associated with the RNA expression of many other genes, with 327 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL33-associated genes across cancer lineages are MIR6076, OR4D9, and MIR101-1. Each is linked with KLHL33 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL33-to-partner and partner-to-KLHL33 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL33→partner) and Y-score (partner→KLHL33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR6076 →	+0.534	+4.308	<.001	.007	3	2
LIHC	OR4D9 →	+0.058	+5.479	<.001	.002	3	2
LIHC	MIR101-1 →	+0.586	+4.915	<.001	.002	3	2
LIHC	TRGV11 →	+0.072	+5.676	<.001	.001	3	2
LIHC	RPL10P10 →	+0.094	+4.607	<.001	.004	3	2
LIHC	GJA6P →	+0.074	+5.008	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 327 associations by consensus.

Exploration

KLHL33 survival (RNA) · tumor vs normal (RNA) · all KLHL33 data types