Across TCGA pan-cancer cohorts, KLHL33 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated KLHL33 data layer compared with 5 for mutation status.

The strongest signal is observed in thyroid carcinoma (THCA), where higher KLHL33 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KLHL33 expression acts as an unfavorable survival marker, although some lineages such as KIRC and PAAD show a favorable association.

THCA, KIRC, and LGG are the cancer types where KLHL33 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Median	All	0.881	0.983	<.001	59	view →
KIRC	DFS	Tertile	All	0.737	0.586	.002	57	view →
LGG	OS	Median	All	0.753	0.867	<.001	43	view →
COAD	DFS	Quartile	All	0.693	0.877	.002	35	view →
PAAD	DFS	Median	II,III,IV	0.379	0.222	.007	24	view →
SKCM	OS	Median	IV	0.882	0.472	.009	24	view →
UCEC	DFS	Median	IV	0.888	0.506	.002	24	view →
BRCA	OS	Tertile	III,IV	0.887	0.758	.010	18	view →
LUAD	OS	Tertile	All	0.867	0.775	.005	17	view →
UVM	DFS	Median	All	0.275	0.740	.018	16	view →
LUSC	DFS	Tertile	III,IV	0.271	0.930	.007	12	view →
OV	OS	Quartile	All	0.783	0.882	.016	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

Exploration

Same gene, other analysis: KLHL33 tumor-vs-normal RNA expression · all KLHL33 data types