Across TCGA patient cohorts, KLHL33 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL33-associated genes across cancer lineages are 14-3-3_beta, Notch1, and ATM. Each is linked with KLHL33 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL33-to-partner and partner-to-KLHL33 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL33→partner) and Y-score (partner→KLHL33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.124	-2.973	.014	.035	3	1
UCEC	Notch1 →	+0.162	+2.820	.022	.035	3	1
UCEC	ATM →	-0.592	-2.321	.009	.035	3	1
UCEC	beta-Catenin →	+0.556	+3.000	.029	.036	2	1
UCEC	JNK2 →	+0.253	+2.321	.011	.035	1	1
UCEC	Annexin-1 →	+0.937	+2.321	<.001	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

KLHL33 survival (RNA) · tumor vs normal (RNA) · all KLHL33 data types