KLHL30

Across TCGA patient cohorts, KLHL30 mutation is significantly associated with the RNA expression of many other genes, with 861 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL30-associated genes across cancer lineages are MIR5588, MIR8053, and DGKE. Each is linked with KLHL30 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL30-to-partner and partner-to-KLHL30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5588 grouped by KLHL30-low versus KLHL30-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL30→partner) and Y-score (partner→KLHL30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR5588 →	+0.279	+3.435	.001	.005	3	2
UCEC	MIR8053 →	+0.169	+2.997	.002	.006	3	2
UCEC	DGKE →	+0.431	+2.584	.007	.001	3	2
UCEC	UTP15 →	+0.395	+3.708	.004	<.001	3	2
UCEC	GFM2 →	+0.597	+2.787	.001	.002	3	2
UCEC	SMIM4 →	+0.423	+2.130	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 861 associations by consensus.

MIR5588 by KLHL30 expression — COAD

Explore this box plot interactively →