KLHL30

Across TCGA cell cohorts, KLHL30 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,998 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible KLHL30-associated GO terms across cancer lineages are Negative regulation of protein polymerization, Negative regulation of actin filament polymerization, and Basement membrane disassembly. Each is linked with KLHL30 in more than 8 cancer types. Because this analysis shows association rather than direction, both KLHL30-to-partner and partner-to-KLHL30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein polymerization grouped by KLHL30-low versus KLHL30-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL30→partner) and Y-score (partner→KLHL30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of protein polymerization →	+0.114	+0.535	<.001	<.001	3	9
PANCREAS	Negative regulation of actin filament polymerization →	+0.132	+0.626	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Basement membrane disassembly →	+1.454	+0.226	<.001	<.001	3	8
PANCREAS	Regulation of actin filament length →	+0.084	+0.576	<.001	<.001	3	8
PANCREAS	Regulation of muscle filament sliding →	+1.144	+0.555	.001	.006	3	8
OESOPHAGUS	Regulation of actin polymerization or depolymerization →	+0.101	+0.467	<.001	.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,998 associations by consensus.

Negative regulation of protein polymerization by KLHL30 expression — PANCREAS

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