KLHL30

Across TCGA cell cohorts, KLHL30 mutation is significantly associated with the RNA expression of many other genes, with 383 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL30-associated genes across cancer lineages are CBY1, RNMT, and TNFSF13B. Each is linked with KLHL30 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL30-to-partner and partner-to-KLHL30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by KLHL30-low versus KLHL30-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL30→partner) and Y-score (partner→KLHL30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.684	+3.137	<.001	.007	3	1
LARGE_INTESTINE	RNMT →	+0.692	+3.385	.001	.004	3	1
LARGE_INTESTINE	TNFSF13B →	+0.538	+3.385	<.001	.004	3	1
LARGE_INTESTINE	UBFD1 →	+0.716	+3.299	.001	.004	3	1
LARGE_INTESTINE	FKBP14 →	+0.827	+3.212	.001	.006	3	1
LARGE_INTESTINE	MCM9 →	+0.629	+3.212	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 383 associations by consensus.

CBY1 by KLHL30 expression — LARGE_INTESTINE

Explore this box plot interactively →