KLHL30-AS1

Across TCGA pan-cancer cohorts, KLHL30-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated KLHL30-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher KLHL30-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLHL30-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and SKCM show a favorable association.

UVM, BRCA, and CESC are the cancer types where KLHL30-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.406	0.863	<.001	85	view →
BRCA	OS	Median	IV	0.344	0.711	.010	55	view →
CESC	DFS	Median	II,III,IV	0.694	0.846	.006	30	view →
ACC	OS	Tertile	II,III,IV	0.652	0.902	.017	26	view →
STAD	DFS	Tertile	All	0.547	0.688	.007	24	view →
MESO	OS	Median	IV	0.313	0.731	.010	23	view →
ESCA	OS	Tertile	II,III,IV	0.606	0.348	.008	19	view →
GBM	OS	Quartile	All	0.229	0.502	.002	15	view →
SKCM	OS	Median	IV	0.833	0.307	.002	12	view →
KIRC	DFS	Median	IV	0.241	0.586	.005	12	view →
LUSC	DFS	Median	III,IV	0.195	0.763	.007	12	view →
PAAD	DFS	Quartile	All	0.348	0.522	.029	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

KLHL30-AS1–UVM (DFS)

Open the UVM breakdown →