KLHL30-AS1

Across TCGA pan-cancer cohorts, KLHL30-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KLHL30-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where KLHL30-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types KLHL30-AS1 is over-expressed in tumor, although a few such as BLCA and LUSC show the opposite, repressed pattern.

BLCA, LUSC, and KICH are the cancer types where KLHL30-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHL30-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−1.482	<.001	11	view →
LUSC	All	III,IV	−0.198	<.001	8	view →
KICH	Female	All	−0.183	<.001	8	view →
KIRC	All	II,III,IV	−0.130	<.001	8	view →
THCA	Male	II,III,IV	−0.486	<.001	7	view →
COAD	All	II,III,IV	−0.125	<.001	7	view →
BRCA	Female	II,III,IV	−0.123	<.001	6	view →
UCEC	All	III,IV	−0.266	.033	4	view →
PRAD	All	All	−0.275	<.001	2	view →
STAD	All	All	−0.216	.027	1	view →
CHOL	All	All	+0.140	.044	1	view →
LUAD	Female	All	−0.071	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KLHL30-AS1–BLCA

Open the BLCA breakdown →