KLHL3

Across TCGA patient cohorts, KLHL3 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,903 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible KLHL3-associated proteins across cancer lineages are TLN2, LRP1, and MAP1A_S667. Each is linked with KLHL3 in more than 6 cancer types. Because this analysis shows association rather than direction, both KLHL3-to-partner and partner-to-KLHL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL3 versus TLN2 in BRCA, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL3→partner) and Y-score (partner→KLHL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TLN2 →	+0.499	+0.651	<.001	<.001	3	7
BRCA	LRP1 →	+0.429	+0.629	<.001	<.001	3	7
LSCC	MAP1A_S667 →	+0.684	+0.549	<.001	<.001	3	7
BRCA	PPP1R12A →	+0.263	+0.536	<.001	.002	3	6
BRCA	PRKG1 →	+0.649	+0.775	<.001	<.001	3	6
HNSC	MAPRE3 →	+0.473	+0.629	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,903 associations by consensus.

KLHL3 vs TLN2 — BRCA

Explore this scatter interactively →