KLHL29

Across TCGA patient cohorts, KLHL29 mutation is significantly associated with the RNA expression of many other genes, with 1,681 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL29-associated genes across cancer lineages are MTMR11, SLC7A11, and NOCT. Each is linked with KLHL29 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL29-to-partner and partner-to-KLHL29 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTMR11 grouped by KLHL29-low versus KLHL29-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL29→partner) and Y-score (partner→KLHL29) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTMR11 →	-1.255	-3.321	<.001	.009	3	2
COAD	SLC7A11 →	+1.133	+3.584	<.001	.002	3	2
UCEC	NOCT →	+0.601	+1.765	<.001	<.001	3	2
UCEC	CENPU →	+0.552	+1.354	.001	.008	3	2
UCEC	SLC25A4 →	+0.513	+1.765	<.001	<.001	3	2
UCEC	GUF1 →	+0.355	+1.541	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,681 associations by consensus.

MTMR11 by KLHL29 expression — COAD

Explore this box plot interactively →