KLHL26

Across TCGA pan-cancer cohorts, KLHL26 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated KLHL26 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KLHL26 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KLHL26 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where KLHL26 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.324	0.663	.004	24	view →
CCRCC	OS	Quartile	All	0.967	0.795	.006	19	view →
UCEC	DFS	Tertile	All	0.904	1.000	.016	12	view →
HNSC	OS	Median	II,III,IV	0.907	0.753	.013	8	view →
LSCC	OS	Tertile	All	0.929	1.000	.018	7	view →
LUAD	OS	Tertile	II,III,IV	0.314	0.899	.001	6	view →
GBM	OS	Quartile	All	0.778	0.493	.012	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

KLHL26–PDAC (OS)

Open the PDAC breakdown →