KLHL26

Across TCGA pan-cancer cohorts, KLHL26 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of KLHL26’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KLHL26 RNA is repressed in tumor relative to normal tissue. In most cancer types KLHL26 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where KLHL26 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLHL26 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.592	<.001	12	view →
HNSC	Male	III,IV	+0.765	<.001	8	view →
LIHC	Female	All	+0.709	<.001	6	view →
COAD	Female	All	+0.554	.002	4	view →
CHOL	All	All	+1.271	<.001	3	view →
KIRP	All	All	−0.370	<.001	3	view →
BLCA	Male	IV	−0.892	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

KLHL26–KIRC

Open the KIRC breakdown →