KLHL26

Across TCGA patient cohorts, KLHL26 mutation is significantly associated with the RNA expression of many other genes, with 531 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL26-associated genes across cancer lineages are FXN, SPATA5L1, and PIGPP2. Each is linked with KLHL26 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL26-to-partner and partner-to-KLHL26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FXN grouped by KLHL26-low versus KLHL26-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL26→partner) and Y-score (partner→KLHL26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FXN →	+0.504	+3.202	.009	.009	3	2
UCEC	SPATA5L1 →	+0.603	+3.332	.003	.005	3	2
SKCM	PIGPP2 →	+0.025	+3.897	<.001	.009	3	2
BLCA	MIR5697 →	+1.014	+4.299	<.001	.007	3	2
SKCM	EDARADD →	-0.595	-3.402	.007	.005	3	2
UCEC	TFDP1 →	+0.749	+3.375	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 531 associations by consensus.

FXN by KLHL26 expression — UCEC

Explore this box plot interactively →