KLHL26

Across TCGA cell cohorts, KLHL26 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,674 significant associations in total. BONE shows the largest number of these associations.

The most reproducible KLHL26-associated GO terms across cancer lineages are Regulation of protein localization to nucleus, Negative regulation of transcription initiation by RNA polymerase II, and Negative regulation of DNA-templated transcription initiation. Each is linked with KLHL26 in more than 15 cancer types. Because this analysis shows association rather than direction, both KLHL26-to-partner and partner-to-KLHL26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to nucleus grouped by KLHL26-low versus KLHL26-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL26→partner) and Y-score (partner→KLHL26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of protein localization to nucleus →	+0.079	+0.982	<.001	<.001	3	16
PANCREAS	Negative regulation of transcription initiation by RNA polymerase II →	+0.118	+0.695	<.001	.003	3	15
PANCREAS	Negative regulation of DNA-templated transcription initiation →	+0.118	+0.695	<.001	.003	3	15
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.135	+0.839	.002	.008	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA splicing, via spliceosome →	+0.123	+1.039	<.001	<.001	3	14
PANCREAS	Negative regulation of mRNA processing →	+0.098	+0.842	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,674 associations by consensus.

Regulation of protein localization to nucleus by KLHL26 expression — SOFT_TISSUE

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