KLHL26

Across TCGA cell cohorts, KLHL26 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLHL26-associated genes across cancer lineages are SCGB1C1, LINGO4, and NPFFR1. Each is linked with KLHL26 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL26-to-partner and partner-to-KLHL26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1C1 grouped by KLHL26-low versus KLHL26-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL26→partner) and Y-score (partner→KLHL26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SCGB1C1 →	+0.055	+4.977	<.001	.002	3	2
SOFT_TISSUE	LINGO4 →	+0.035	+4.222	<.001	.007	3	1
BLOOD_Leukemia	NPFFR1 →	+0.011	+3.359	<.001	.002	3	1
BLOOD_Leukemia	TMEM132C →	+0.653	+3.381	<.001	.002	3	1
BLOOD_Leukemia	TBPL2 →	+0.071	+4.366	<.001	<.001	3	1
BLOOD_Leukemia	IGFL1 →	+0.066	+3.091	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

SCGB1C1 by KLHL26 expression — SOFT_TISSUE

Explore this box plot interactively →