KLHL25

Across TCGA patient cohorts, KLHL25 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,712 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KLHL25-associated proteins across cancer lineages are ACLY, SH3BP4, and CTDSPL2. Each is linked with KLHL25 in more than 5 cancer types. Because this analysis shows association rather than direction, both KLHL25-to-partner and partner-to-KLHL25 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL25 versus ACLY in OV, with a Pearson correlation of -0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL25→partner) and Y-score (partner→KLHL25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ACLY →	-0.430	-0.714	<.001	<.001	3	6
LSCC	SH3BP4 →	+0.396	+0.436	<.001	.003	3	5
GBM	CTDSPL2 →	+0.479	+0.807	<.001	<.001	3	5
OV	PHC1_S664 →	+0.999	+0.458	.007	.009	3	5
GBM	ZNF609 →	+0.337	+0.617	<.001	<.001	3	4
GBM	ZNF609_S576 →	+0.357	+0.789	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,712 associations by consensus.

KLHL25 vs ACLY — OV

Explore this scatter interactively →