KLHL25

Across TCGA patient cohorts, KLHL25 protein abundance is significantly associated with the RNA expression of many other genes, with 8,790 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KLHL25-associated genes across cancer lineages are FHL2, PDE6G, and MATN1-AS1. Each is linked with KLHL25 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL25-to-partner and partner-to-KLHL25 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL25 versus FHL2 in LUAD, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL25→partner) and Y-score (partner→KLHL25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FHL2 →	+1.277	+0.475	<.001	.003	3	3
UCEC	PDE6G →	-0.924	-0.430	.001	<.001	3	3
BRCA	MATN1-AS1 →	-0.564	-0.527	<.001	.001	3	3
LUAD	HLA-F-AS1 →	-0.716	-0.501	.002	<.001	3	3
LUAD	TERF1P7 →	-0.556	-0.613	<.001	<.001	3	3
CCRCC	ERICH6 →	-0.371	-0.604	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,790 associations by consensus.

KLHL25 vs FHL2 — LUAD

Explore this scatter interactively →