KLHL25

Across TCGA patient cohorts, KLHL25 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL25-associated genes across cancer lineages are eIF4G, A-Raf_pS299, and Bap1-c-4. Each is linked with KLHL25 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL25-to-partner and partner-to-KLHL25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by KLHL25-low versus KLHL25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL25→partner) and Y-score (partner→KLHL25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.271	+2.000	.007	.029	3	2
UCEC	A-Raf_pS299 →	-0.133	-2.415	<.001	.003	3	2
UCEC	Bap1-c-4 →	+0.142	+1.604	.045	.021	3	2
UCEC	Caspase-7-cleavedD198 →	+0.550	+1.459	.004	.012	3	2
UCEC	C-Raf →	+0.140	+1.678	.002	.021	3	2
UCEC	Cyclin-B1 →	+0.436	+1.584	.016	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

eIF4G by KLHL25 expression — UCEC

Explore this box plot interactively →