KLHL25

Across TCGA cell cohorts, KLHL25 mutation is significantly associated with the RNA expression of many other genes, with 139 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL25-associated genes across cancer lineages are OR52K2, OR52K1, and MIOX. Each is linked with KLHL25 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL25-to-partner and partner-to-KLHL25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52K2 grouped by KLHL25-low versus KLHL25-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL25→partner) and Y-score (partner→KLHL25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR52K2 →	+0.130	+5.357	<.001	.001	3	1
CNS	OR52K1 →	+0.042	+4.754	<.001	.005	3	1
LARGE_INTESTINE	MIOX →	+0.291	+3.087	<.001	.006	3	1
LARGE_INTESTINE	VAPA →	+0.614	+3.364	.001	.002	3	1
LARGE_INTESTINE	C1QBP →	+0.721	+3.131	.001	.008	3	1
LARGE_INTESTINE	MPV17 →	-0.534	-3.278	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 139 associations by consensus.

OR52K2 by KLHL25 expression — CNS

Explore this box plot interactively →