KLHL24

Across TCGA pan-cancer cohorts, KLHL24 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KLHL24 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KLHL24 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KLHL24 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

LUAD, HNSC, and GBM are the cancer types where KLHL24 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	III,IV	0.160	0.845	.010	24	view →
HNSC	OS	Median	All	0.689	1.000	.011	14	view →
GBM	OS	Median	All	0.796	0.368	.017	7	view →
LSCC	DFS	Quartile	II,III,IV	0.887	0.198	.024	3	view →
PDAC	OS	Quartile	II,III,IV	0.822	0.399	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KLHL24–LUAD (OS)

Open the LUAD breakdown →