KLHL22

Across TCGA patient cohorts, KLHL22 RNA expression is significantly associated with the RNA expression of many other genes, with 19,857 significant associations in total. ACC shows the largest number of these associations.

The most reproducible KLHL22-associated genes across cancer lineages are CRTC1, LZTR1, and HIRA. Each is linked with KLHL22 in more than 32 cancer types. Because this analysis shows association rather than direction, both KLHL22-to-partner and partner-to-KLHL22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL22 versus CRTC1 in SCLC, with a Pearson correlation of 0.63.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL22→partner) and Y-score (partner→KLHL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	CRTC1 →	+1.294	+0.878	<.001	<.001	3	33
SCLC	LZTR1 →	+1.019	+0.959	<.001	<.001	3	33
ACC	HIRA →	+1.211	+1.180	<.001	<.001	3	31
SCLC	PWWP3A →	+0.912	+0.728	<.001	<.001	3	31
SCLC	CBX6 →	+1.481	+0.787	<.001	<.001	3	31
SCLC	ZNF70 →	+1.142	+1.001	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,857 associations by consensus.

KLHL22 vs CRTC1 — SCLC

Explore this scatter interactively →