KLHL22

Across TCGA patient cohorts, KLHL22 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,064 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KLHL22-associated proteins across cancer lineages are ZNF609, ARVCF, and ACTR2. Each is linked with KLHL22 in more than 4 cancer types. Because this analysis shows association rather than direction, both KLHL22-to-partner and partner-to-KLHL22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL22 versus ZNF609 in GBM, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL22→partner) and Y-score (partner→KLHL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ZNF609 →	+0.297	+0.326	<.001	<.001	3	4
UCEC	ARVCF →	+0.627	+0.660	<.001	<.001	2	5
GBM	ACTR2 →	-0.186	-0.404	<.001	<.001	3	4
CCRCC	CEBPB →	-0.441	-0.248	<.001	<.001	3	4
LSCC	CRKL →	+0.367	+0.529	<.001	.001	3	4
GBM	KLHL22_T605 →	+0.411	+0.544	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,064 associations by consensus.

KLHL22 vs ZNF609 — GBM

Explore this scatter interactively →