KLHL22

Across TCGA patient cohorts, KLHL22 protein abundance is significantly associated with the RNA expression of many other genes, with 7,442 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible KLHL22-associated genes across cancer lineages are SERPINF1, CDH11, and COL6A2. Each is linked with KLHL22 in more than 4 cancer types. Because this analysis shows association rather than direction, both KLHL22-to-partner and partner-to-KLHL22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL22 versus SERPINF1 in OV, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL22→partner) and Y-score (partner→KLHL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPINF1 →	+1.570	+0.465	<.001	.001	3	5
OV	CDH11 →	+1.155	+0.324	<.001	<.001	3	5
OV	COL6A2 →	+1.963	+0.574	<.001	<.001	3	5
BRCA	KCNE4 →	+2.239	+0.283	<.001	<.001	3	5
LSCC	EFEMP2 →	+0.696	+0.252	<.001	<.001	3	5
BRCA	SEMA3C →	+1.247	+0.192	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,442 associations by consensus.

KLHL22 vs SERPINF1 — OV

Explore this scatter interactively →