KLHL22

Across TCGA patient cohorts, KLHL22 protein abundance is significantly associated with the protein abundance of many other proteins, with 13,346 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KLHL22-associated proteins across cancer lineages are KLHL22_T605, MRC2, and SPECC1L. Each is linked with KLHL22 in more than 7 cancer types. Because this analysis shows association rather than direction, both KLHL22-to-partner and partner-to-KLHL22 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL22 versus KLHL22_T605 in HNSC, with a Pearson correlation of 0.45.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL22→partner) and Y-score (partner→KLHL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KLHL22_T605 →	+0.452	+0.329	<.001	<.001	3	8
OV	MRC2 →	+0.511	+0.409	<.001	<.001	3	6
OV	SPECC1L →	+0.407	+0.471	<.001	<.001	3	5
LSCC	WDR43 →	-0.333	-0.233	<.001	<.001	3	5
OV	RAE1 →	-0.309	-0.475	<.001	<.001	3	5
LSCC	C1orf35 →	-0.432	-0.264	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,346 associations by consensus.

KLHL22 vs KLHL22_T605 — HNSC

Explore this scatter interactively →