KLHL22

Across TCGA patient cohorts, KLHL22 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL22-associated genes across cancer lineages are PKC-b-II_pS660, ERK2, and MEK1. Each is linked with KLHL22 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL22-to-partner and partner-to-KLHL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by KLHL22-low versus KLHL22-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL22→partner) and Y-score (partner→KLHL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PKC-b-II_pS660 →	-0.412	-3.000	.013	.035	3	2
UCEC	ERK2 →	+0.179	+2.459	.018	.019	3	2
UCEC	MEK1 →	+0.354	+2.000	.013	.010	3	2
UCEC	PCNA →	+0.204	+1.584	.016	.036	3	2
UCEC	ATM →	-0.505	-1.584	.004	.036	3	2
UCEC	4E-BP1 →	+0.286	+2.000	.007	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

PKC-b-II_pS660 by KLHL22 expression — COAD

Explore this box plot interactively →