KLHL22

Across TCGA cell cohorts, KLHL22 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,244 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL22-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cellular anatomical structure, Symbiont-mediated disruption of host anatomical structure, and Cell division. Each is linked with KLHL22 in more than 16 cancer types. Because this analysis shows association rather than direction, both KLHL22-to-partner and partner-to-KLHL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cellular anatomical structure grouped by KLHL22-low versus KLHL22-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL22→partner) and Y-score (partner→KLHL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Symbiont-mediated disruption of host cellular anatomical structure →	+0.193	+1.256	<.001	.002	3	17
OESOPHAGUS	Symbiont-mediated disruption of host anatomical structure →	+0.193	+1.256	<.001	.002	3	17
LUNG_NSCLC_LUSC	Cell division →	+0.099	+0.819	.001	.003	3	14
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.074	+1.324	<.001	.001	3	14
KIDNEY	Cytosolic transport →	+0.077	+1.008	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Mitotic cytokinesis →	+0.093	+0.851	.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,244 associations by consensus.

Symbiont-mediated disruption of host cellular anatomical structure by KLHL22 expression — OESOPHAGUS

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