KLHL22

Across TCGA cell cohorts, KLHL22 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLHL22-associated genes across cancer lineages are GP9, CLDN8, and TLX3. Each is linked with KLHL22 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL22-to-partner and partner-to-KLHL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GP9 grouped by KLHL22-low versus KLHL22-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL22→partner) and Y-score (partner→KLHL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GP9 →	+0.025	+5.754	<.001	.002	3	2
BLOOD_Leukemia	CLDN8 →	+0.012	+4.234	<.001	.003	3	1
BLOOD_Leukemia	TLX3 →	+1.448	+3.944	.002	.006	3	1
BLOOD_Leukemia	KRT6C →	+0.026	+4.037	<.001	.004	3	1
BLOOD_Leukemia	PRM3 →	+0.054	+4.984	<.001	.002	3	1
BLOOD_Leukemia	DEFB125 →	+0.028	+4.060	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

GP9 by KLHL22 expression — CNS

Explore this box plot interactively →