KLHL21

Across TCGA patient cohorts, KLHL21 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,100 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KLHL21-associated proteins across cancer lineages are MECR, CXCL14, and SRP54. Each is linked with KLHL21 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLHL21-to-partner and partner-to-KLHL21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL21 versus MECR in CCRCC, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL21→partner) and Y-score (partner→KLHL21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MECR →	+0.334	+0.411	.001	.001	3	4
LSCC	CXCL14 →	+1.555	+0.569	<.001	<.001	3	3
LSCC	SRP54 →	-0.277	-0.586	<.001	.001	3	3
LSCC	MRTO4 →	+0.350	+0.750	<.001	<.001	3	3
LSCC	NECTIN4_S426 →	+0.912	+0.545	<.001	.001	3	3
BRCA	PDCD4_T93 →	+0.665	+0.644	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,100 associations by consensus.

KLHL21 vs MECR — CCRCC

Explore this scatter interactively →